In the beginning of the human race there was no genetic load which would cause undesirable traits such as appear in offspring of marriages between relatives today.
Seen from the United States or Europe, Iran's nuclear program often causes most concern, but from the perspective of countries in the Asia-Pacific region, the North Korean program is equally worrying.
Certainly if we hope do enhance and extend whatever natural assets we were given, we must expect to make an effort, if not actually great labor.