It's very clearly stated in the film: You make your own choices, and what you're always fighting is ego.
“It's weird to say, but every time I look at my daughter and I see this little living breathing thing that came from me, that represents all of the hopes and dreams that I would want for her, I see a miracle.”
“There will be statues of Bill Gates across the Third World. There's a reasonable shot that - because of his money - we will cure malaria.”