Self-esteem is as important to our well-being as legs are to a table. It is essential for physical and mental health and for happiness.
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I just feel that no matter what comes in a career - and mine has been all over the map - you must stay at the table, pick up the cards you're dealt and play them.
At one time I thought the Editor of the Lancet would kindly publish a letter from me on the subject, but further reflection led me to doubt whether so insignificant an individual would be noticed without some special introduction.