Girls in scripts are often pretty but brainless, or geeky and no one likes them, so it's great to find richer roles. Chalk and cheese aspects of people are very interesting to play.
But I also think all of the great stories in literature deal with loneliness. Sometimes it's by way of heartbreak, sometimes it's by way of injustice, sometimes it's by way of fate. There's an infinite number of ways to examine it.