I was directed because I knew I wanted to be a novelist, but I didn't have a very good job or a way of getting published. I found those years to be among the most difficult of my life.
The first serious applications were in triterpenoid chemistry.
If you want something, have it. If you feel like it's forbidden, you'll want it even more. Whenever I have a craving, I go and have it and just make sure I don't have it again the next day.