Everyone needs a certain amount of money. Beyond that, we pursue money because we know how to obtain it. We don't necessarily know how to obtain happiness.
I think what actually works best is local-level individual targeting of key leadership nodes.
It is possible that a scientific discovery will be made that humans will later regret because it has awful consequences. The problem is, we probably would not know in advance and, once the discovery is made, it cannot be undiscovered.

