As they say in the bible, that you're supposed to rejoice when people die and mourn when they're born, because it's one of the most painful acts you go through in life, is being born, and dying.
I certainly saw science as a kind of calling, and one with as much legitimacy as a religious calling.
I have friends that are much better actors than I am that had to quit the business because they couldn't survive the auditions or the rejections, or people just didn't realize how good they were.

