I think people stop themselves from doing the things they want to do. I just think you never know how long you're going to be around so you might as well do the things that are intriguing. Nobody really cares anyway so you have to do what makes you happy.
I'm more of a writer than an actor, and I used to say that I'm mostly an improviser, though I haven't improvised in awhile.
Occasionally I do things against my inner voice, but you really should go for the thing that touches you most-even if you don't quite know why it does.