I had some years of definite frustration. Auditioning and not working as much as I would have liked to, or working and being paid a pittance, and sort of scrounging by in New York and sleeping on a chair that folded out into a bed.
Progress is a nice word. But change is its motivator. And change has its enemies.
Well, in pharmacology, if the effect is local, it's of course absolutely awkward to use it in any other way than as a local treatment.

