I can't really put it in one sentence because although on one hand Preacher is about faith and yes it is also about, I suppose, the search for God, the search for faith and the manipulation and the abuse committed by figures in whom I suppose people have faith.
“God almighty made women and the Rockefeller gang of thieves made the ladies.”
“I have sworn to only live free. Even if I find bitter the taste of death, I don't want to die humiliated or deceived.”