Usually when you're working is when people want you to work. They don't want you as much when you're not working. That's the frustrating nature of our business.
Cosmologists have attempted to account for the day-to-day laws you find in textbooks in terms of fundamental 'superlaws,' but the superlaws themselves must still be accepted as brute facts. So maybe the ultimate laws of nature will always be off-limits to science.
A trip to space is a big motivator to give up some things in your personal life. Obviously, you can't give up everything and you don't want to.

