Always, your work is the same: You have to tell a story, you have to make a character. It doesn't matter if there are thousands of dollars, millions behind it, or if there is nothing.
I am, incidentally, the only writer to have received the Somerset Maugham award twice - the first time for my first novel, the second time for my second first novel.
Science doesn't in the slightest depend on trust. It depends completely on the belief that you can demonstrate something for yourself.