X-Ray crystallography is nowadays an accurate and rapid method of determining conformation in the crystal lattice, which conformation usually corresponds to the preferred conformation in solution.
If you ask me a question, don't tell me what the question is in advance, 'cause I'd rather not know.
That's why, when Alias came along, I knew I'd be OK if the show was on for five or six years because the writing was so good and the creative team was so strong.