It does not seem, however, that organic chemists were much worried about barriers to rotation in organic molecules in general at that time because there was no technique available to demonstrate the phenomenon experimentally.
“I have had issues with depression all my life, and it's probably true to say there was a tendency towards it even when I was very young, during my schooldays. There was often - and this is quite common with comics - a sense of not feeling as if I belonged anywhere.”