It does not seem, however, that organic chemists were much worried about barriers to rotation in organic molecules in general at that time because there was no technique available to demonstrate the phenomenon experimentally.
“Once a novel gets going and I know it is viable, I don't then worry about plot or themes. These things will come in almost automatically because the characters are now pulling the story.”
“Further, the dignity of the science itself seems to require that every possible means be explored for the solution of a problem so elegant and so celebrated.”