It's good not only to realize that you can't please all of the people all of the time, but that you don't want to. There's a certain type of reader that you don't ever want to write for.
“I used to be a classic workaholic, and after seeing how little work and career really mean when you reach the end of your life, I put a new emphasis on things I believe count more. These things include: family, friends, being part of a community, and appreciating the little joys of the average day.”