I'm a working actor so I never really pick a film because of a genre, and I don't really turn them down because of genre. Anything that's unlike the picture I just finished is always more interesting.
It does not seem, however, that organic chemists were much worried about barriers to rotation in organic molecules in general at that time because there was no technique available to demonstrate the phenomenon experimentally.
Everything that works in sales has been done already. Just keep track of the crap that you buy, or the awesome stuff that you buy, and decide what was the trigger, and then just sell to people like you. It's really that easy - and that's what I do.