The Simpsons can go anywhere in the world and not worry about any budgetary issues. However, even when the show has had its run, I think the characters can go on in perpetuity.
“I think the reason why we were able to actually get it made was that we were so extremely naive - we had no experience at all here. We didn't even know that you were supposed to have an agent. We didn't even have a lawyer. We didn't know one soul.”