I guess when somebody offers you a movie, you don't say no. That's what I've learned.
What does gene A do? What does gene B do? What does it do in different contexts? What's its importance? We know the answer to that for a very small number of genes, the ones that made themselves evident many years ago.
In Britain, you do your job. When you do an American TV show, there is a sense of being one with the crew, and there is a leadership element, which was a learning curve for me because it is very different culturally. In Britain, you just do it, leave and say, 'Thanks.'