I always thought the biggest failing of Americans was their lack of irony. They are very serious there! Naturally, there are exceptions... the Jewish, Italian, and Irish humor of the East Coast.
So I'm not really quite sure what Landis' plans were to make another one. The American Werewolf in Paris was a completely separate story.
When I was a young man, I was overly sensitive to things, and I found it difficult to eat when I was nervous.