Shows can come and go. They can be a hit and then in three years, gone. There's some comfort in having the stability of a job and having children. It's a double-edged sword.
My friends and I make short films. We pretended to rob the Dairy Queen where our friend worked, but someone thought we were real thieves and called the cops! Soon, the cops burst in with guns drawn!
Well, in pharmacology, if the effect is local, it's of course absolutely awkward to use it in any other way than as a local treatment.