One of the main pitfalls of any theoretically 'niche' show is that you spend too much time on the 'niche' and not enough time on the 'show.'
Often as a child you see someone with a learning disability or Down's Syndrome and my mum and dad were always very quick to explain exactly what was going on and to be in their own way inclusive and welcoming.
Comparing Apple to Netflix is like comparing apples to oranges, especially if the oranges made so many mistakes that people stopped eating oranges and just went back to Blockbuster.

