Well, in pharmacology, if the effect is local, it's of course absolutely awkward to use it in any other way than as a local treatment.
“I'm home schooled, and I have a teacher that goes with me on all my movies.”
“So it's mix and match. Hold your line when you really feel something you're saying is wonderful and you really want to get this point across and prove it to your partner by just throwing it into the tape and letting it speak for itself.”