Well, in pharmacology, if the effect is local, it's of course absolutely awkward to use it in any other way than as a local treatment.
“A rude nature is worse than a brute nature by so much more as man is better than a beast: and those that are of civil natures and genteel dispositions are as much nearer to celestial creatures as those that are rude and cruel are to devils.”
“We should because when coaches get fired, the players have a lot to do with it.”